A full Apr 1, 1974 · Aims: In a systematic screening of the World Health Organization Adverse Drug Reaction database, VigiBase, in July 2008, a measure of association used to detect interactions (Omega) highlighted azithromycin with the individual statins atorvastatin, lovastatin and simvastatin and rhabdomyolysis
Antiarrhythmics
Published 24 November 2023 Topics: Atorvastatin · Azithromycin · Clarithromycin · 7 more The use of statins can be continued with azithromycin
Medicine safety Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements
For example, taking a cough medicine ( antitussive) and a drug to help
Their outcomes
Azithromycin is used to treat certain bacterial infections in many different parts of the body
Statins, specifically fluvastatin, lovastatin, rosuvastatin, and simvastatin may interact with warfarin
Thereafter, simvastatin was replaced with rosuvastatin and he was also asked to avoid macrolide antibiotics in future
He presented with weakness of all extremities with a significant increase in creatinine phosphokinase levels and acute kidney injury
Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan
HMG-CoA reductase inhibitors, also known as statins, are widely used as the mainstay therapy for the management of dyslipidaemia, including primary and secondary prevention of cardio- and cerebrovascular disease
In many cases, these interactions can increase the risk of muscle pain and damage
It is also sold in combination with ezetimibe as Vytorin, and niacin as Simcor
Using clarithromycin together with simvastatin is not recommended
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In the first case devel- He had been receiving simvastatin 80 mg/day for the past 2 years
Drug interactions can differ with various statins, including Crestor (rosuvastatin), Lescol (fluvastatin), Lipitor (atorvastatin), Mevacor (lovastatin), Pravachol (pravastatin), or Zocor (simvastatin)
Rhabdomyolysis could have been caused by a drug interaction between simvastatin with azithromycin (Alreja, Inayatullah, Goel, & Braden, 2012)
Nevertheless, the co-prescription of a CYP3A4 inhibitor may lead to an increase in the plasma concentration of either statin, increasing the risk of adverse Macrolides are a class of antibiotics that have different effects on drug metabolism and interactions